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5 Best Sinus Medicines of 2026

Last Updated - 2026/05/22

1
Best Choice

✖
Our rankings are cleverly generated from the algorithmic analysis of thousands of customer reviews about products, brands, merchant’s customer service level, popularity, trends and more. The rankings reflect our opinion and should be a good starting point for shopping.

Mucinex

Mucinex Multi-Action Congestion,Cold & Flu Caplets, 20 count

Mucinex

CA$17.99

More Details
Main highlights
- Use as directed
- Relief from chest and nasal congestion, sinus pressure, headaches and fever
- One dose, all cold & Flu symptoms
- 3 active ingredients
- 200mg guaifenesin to help loosen mucus and make coughs more productive
CA$17.99
2

✖
Our rankings are cleverly generated from the algorithmic analysis of thousands of customer reviews about products, brands, merchant’s customer service level, popularity, trends and more. The rankings reflect our opinion and should be a good starting point for shopping.

NEOCITRAN

NeoCitran Extra Strength Cold and Congestion for Non-Drowsy Relief, Lemon, 10 Count

NEOCITRAN

CA$17.79

More Details
Main highlights
- Try the nighttime formula from NeoCitran when you need to relieve your cold and flu symptoms so you can get a good night of rest
- Suitable for adults and children ages 12 and older
- Relieves common cold symptoms including headache, sore throat pain, and sinus and nasal congestion
- Extra-strength cold and congestion medicine comes in a non-drowsy formula that's ideal for use during the day
- Dissolve the contents of a single-dose pouch in boiling water to create a soothing, lemon-flavoured beverage
CA$17.79
3

✖
Our rankings are cleverly generated from the algorithmic analysis of thousands of customer reviews about products, brands, merchant’s customer service level, popularity, trends and more. The rankings reflect our opinion and should be a good starting point for shopping.

Tylenol

TYLENOL Extra Strength Sinus eZ Tabs, Relieves Sinus congestion and other sinus Symptoms, Daytime, 40ct

Tylenol

CA$12.77

More Details
Main highlights
- To use, Adults and children 12 years and older, take 1-2 daytime tablets every 4 hours as needed
- Made with 500 mg of Acetaminophen for help relieve pain and reduce fever and 5 mg of Phenylephrine Hydrochloride for nasal decongestion
- Made in an easy-to-swallow tablet form
- Get effective relief of symptoms including nasal congestion, sinus pain and pressure, fever, sore throat, and headache due to the common cold or flu
- 40-count package of Tylenol Sinus Extra Strength Day Time Tablets help relieve your morning sinus symptoms
CA$12.77
4
Best Value
15% Off

✖
Our rankings are cleverly generated from the algorithmic analysis of thousands of customer reviews about products, brands, merchant’s customer service level, popularity, trends and more. The rankings reflect our opinion and should be a good starting point for shopping.

Tylenol
15% Off

TYLENOL Sinus Extra Strength eZ Tabs, Relieves Sinus congestion and other Sinus symptoms, Daytime and Nighttime, Convenience Pack, 40ct

Tylenol

CA$12.77

CA$14.97
(15% Off)

More Details
Main highlights
- Tylenol Sinus Extra Strength Daytime/Nighttime Combo, 24+16 pack, helps relieves your day and night sinus symptoms
- Night tablets also contain 2 mg of Chlorpheniramine Maleate as an antihistamine for runny nose and sneezing
- Get fast, effective relief of symptoms including sinus-related pain and pressure, sinus headache, sinus congestion, aches and pains and runny nose and sneezing (nighttime only) due to the common cold or flu
- For adult uses only (12 years and older). Take 1-2 caplet tablets every 4 hours as needed; Do not exceed a combined total of any 8 caplets in 24 hours
- Each day and night tablet contains 500 mg of Acetaminophen to help relieve pain and reduce fever, 5 mg of Phenylephrine Hydrochloride for nasal decongestion
CA$12.77
CA$14.97 (15% Off)
5

✖
Our rankings are cleverly generated from the algorithmic analysis of thousands of customer reviews about products, brands, merchant’s customer service level, popularity, trends and more. The rankings reflect our opinion and should be a good starting point for shopping.

Tylenol

TYLENOL Extra Strength Cold eZ Tabs, Relieves Cold symptoms, Nighttime, 40ct

Tylenol

CA$12.77

More Details
Main highlights
- To use, Adults and children 12 years and older, take 1-2 nighttime tablets every 4 hours as needed
- Made with 500 mg of Acetaminophen to help relieve pain and reduce fever and 10 mg of Dextromethorphan Hydrobromide to help suppress coughs
- Made with 5 mg of Phenylephrine Hydrochloride to for nasal decongestion, and 2 mg of Chlorpheniramine Maleate antihistamine to help runny noses and sneezing
- Get effective relief of symptoms including: nasal congestion, dry cough, fever, aches and pains, and runny nose and sneezing due to the common cold or flu
- 40-count package of Tylenol Cold Extra Strength Night Time Tablets help relieve your cold symptoms
CA$12.77

5 Best Sinus Medicines of 2026

Mucinex Multi-Action Congestion,Cold & Flu Caplets, 20 count

NeoCitran Extra Strength Cold and Congestion for Non-Drowsy Relief, Lemon, 10 Count

TYLENOL Extra Strength Sinus eZ Tabs, Relieves Sinus congestion and other sinus Symptoms, Daytime, 40ct

TYLENOL Sinus Extra Strength eZ Tabs, Relieves Sinus congestion and other Sinus symptoms, Daytime and Nighttime, Convenience Pack, 40ct

TYLENOL Extra Strength Cold eZ Tabs, Relieves Cold symptoms, Nighttime, 40ct

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NEOCITRAN® ES Cold & Sinus Night Lemon

TYLENOL Extra Strength Cold eZ Tabs, Relieves Cold symptoms, Daytime and Nighttime, Convenience Pack, 40ct

Vicks DayQuil Sinus Relief Liquicap Medicine, Liquid Capsules, Non-Drowsy Multi-Symptom Daytime Relief for Sinus Headaches and Pain, Sinus Congestion, and Sinus Pressure, 24 Liquicaps

Claritin Allergy Decongestant Nasal Spray, Fast Acting Relief, 25ml

BENYLIN Extra Strength Cold and Sinus Caplets, Relieves Cold and Sinus symptoms, Daytime and Nighttime, Convenience Pack, 20ct

TYLENOL Extra Strength Flu eZ Tabs, Relieves Flu symptoms, Daytime, 20ct

Dristan Long Lasting Nasal Mist (30 mL)

Vicks Vapoinhaler Nasal Decongestant with Soothing Vapors for Temporary Relief due to a Cold, Menthol Scent, 2 Pack , 0.20 mL each

Drixoral No Drip Original Unscented Spray with Oxymetazoline, Reduces Swelling and Clears Congestion, Unblocks Noses, Helps Relieve Nasal Congestion, 15ml

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